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Asia-Pacific Crohn's and Colitis Epidemiology Study
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About Us
About Us

The Asia-Pacific Crohn's and Colitis Epidemiology Study is a collaboration project between 11 countries across Asia and Australia, focusing on research of Inflammatory Bowel Disease (IBD) in Asia-Pacific. In the past 2 decades, the incidence of IBD has been increasing in Asia. Yet, the reasons behind such changes remain largely unknown. They are unlikely to be merely increased awareness of the disease and differences in diagnostic practices, but most likely reflect real differences secondary to environmental factors, lifestyle and genetic susceptibility. We aim to fill the knowledge gap in our understanding of the epidemiology and natural history of IBD in Asia and hope to unravel factors responsible for the causation of IBD in Asia.

Since 2010, we meet bi-annually at international Gastroenterology Conferences. We welcome any centers to join our study group. If you are interested in any of our ongoing study, please contact us.

Groups Involved

Australia - Melbourne
St Vincent's Hospital and University of Melbourne, Melbourne, Australia

Australia - Sydney
Concord Hospital, Gastroenterology and Liver Services and The University of New South Wales, Sydney

Brunei
Raja Isteri Pengiran Anak Saleha Hospital

Canada
Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta

China - Chengdu
West China Hospital, Sichuan University

China - Daqing
Peking Union Medical College (PUMC) Hospital

China - Guangzhou
The First Affliated Hospital of Sun Yat-sen University

China - Inner Mongolia
Department of Gastroenterology, Peking Union Medical College Hospital

China - Kunming
The First Affiliated Hospital of Kunming Medical University

China – Wuhan
Zhongnan Hospital, Wuhan University School of Medicine

China - Xian
Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University

China - Xiangshan
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
Xiangshan People’s Hospital, Xiangshan

Hong Kong
Institute of Digestive Disease, Chinese University of Hong Kong
Prince of Wales Hospital
Alice Ho Miu Ling Nethersole Hospital
North District Hospital
United Christian Hospital
Tseung Kwan O Hospitala

India
Asian Institute of Gastroenterology, Hyderabad

Indonesia
Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta

Macau
Kiang Wu Hospital Hospital Conde S Januario

Malaysia
University of Malaya Medical Centre, Kuala Lumpur

Philippines
Metropolitan Medical Center, Manila

Singapore
National University Hospital of Singapore
Singapore General Hospital

Sri Lanka
Colombo North Teaching Hospital, Ragama

Taiwan
National Taiwan University Hospital, Taipei
Taipei-Veterans General Hospital, Taipei
Mackay Memorial Hospital, Taipei

Thailand - Bangkok
King Chulalongkorn Memorial Hospital, Bangkok,
Siriraj Hosptial, Bangkok

Thailand - Chiengmai
Maharaj Nakorn Chiengmai Hospital, Chiengmai

News and Updates
News and Updates

Publications

The Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies
SC Ng#, HY Shi, N Hamidi, FE Underwood, W Tang , EI Benchimol, R Panaccione, S Ghosh, JCY Wu, FKL Chan, JJY Sung, GG Kaplan#. The Lancet. 2017. In Press.
#Equal contribution


Endoscopic and Histologic Mucosal Healing in Ulcerative Colitis in the First Year of Diagnosis: Results from a Population-Based Inception Cohort from Six Countries in Asia
CM Leung, W Tang, M Kyaw, G Niamul, S Aniwan, J Limsrivilai, YF Wang, Q Ouyang, M Simadibrata, M Abdullah, D Ong, HH Yu, J Zhang, J Ching, J Wu, FKL Chan, JJY Sung, and SC Ng. Journal of Crohn's and Colitis. 2017. doi: 10.1093/ecco-jcc/jjx103.


Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia
Ng SC, Zeng Z, Niewiadomski O, Tang W, Bell S, Kamm MA, Hu P, de Silva HJ, Niriella MA, Udara WS, Ong D, Ling KL, Ooi CJ, Hilmi I, Lee Goh K, Ouyang Q, Wang YF, Wu K, Wang X, Pisespongsa P, Manatsathit S, Aniwan S, Limsrivilai J, Gunawan J, Simadibrata M, Abdullah M, Tsang SW, Lo FH, Hui AJ, Chow CM, Yu HH, Li MF, Ng KK, Ching JY, Chan V, Wu JC, Chan FK, Chen M, Sung JJ; Asia-Pacific Crohn’s and Colitis Epidemiology Study (ACCESS) Group. Gastroenterology. 2016 Jan;150(1):86-95.e3. doi: 10.1053/j.gastro.2015.09.005. Epub 2015 Sep 15. PubMed PMID: 26385074


Environmental Risk Factors in Inflammatory Bowel Disease: a Population-based Case-control Study in Asia-Pacific
Ng SC, Tang W, Leong RW, Chen M, Ko Y, Studd C, Niewiadomski O, Bell S, Kamm MA, de Silva HJ, Kasturiratne A, Senanayake YU, Ooi CJ, Ling KL, Ong D, Goh KL, Hilmi I, Ouyang Q, Wang YF, Hu P, Zhu Z, Zeng Z, Wu K, Wang X, Xia B, Li J, Pisespongsa P, Manatsathit S, Aniwan S, Simadibrata M, Abdullah M, Tsang SW, Wong TC, Hui AJ, Chow CM, Yu HH, Li MF, Ng KK, Ching J, Wu JC, Chan FK, Sung JJ; on behalf of the Asia-Pacific Crohn's and Colitis Epidemiology Study (ACCESS) Group. Gut. 2014 Sep 12. pii: gutjnl-2014-307410. doi: 10.1136/gutjnl-2014-307410. [Epub ahead of print] PubMed PMID: 25217388.


Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study
Ng SC, Tang W, Ching JY, Wong M, Chow CM, Hui AJ, Wong TC, Leung VK, Tsang SW, Yu HH, Li MF, Ng KK, Kamm MA, Studd C, Bell S, Leong R, de Silva HJ, Kasturiratne A, Mufeena MN, Ling KL, Ooi CJ, Tan PS, Ong D, Goh KL, Hilmi I, Pisespongsa P, Manatsathit S, Rerknimitr R, Aniwan S, Wang YF, Ouyang Q, Zeng Z, Zhu Z, Chen MH, Hu PJ, Wu K, Wang X, Simadibrata M, Abdullah M, Wu JC, Sung JJ, Chan FK; Asia–Pacific Crohn's and Colitis Epidemiologic Study (ACCESS) Study Group. Gastroenterology. 2013 Jul;145(1):158-165.e2. doi: 10.1053/j.gastro.2013.04.007. Epub 2013 Apr 9. PubMed PMID: 23583432.

Play Video Abstract


Current Studies
Current Studies

Temporal Trends of IBD in Asia-Pacific

IBD is increasing in Asia, however, the rate and frequency of increase is unknown. Temporal trends study will allow us to estimate the burden of IBD in the future. We plan to investigate disease incidence over the next 5 years.

IBD Healthcare Economics

IBD is a chronic diesase with a young age of onset. Its effects on health-care systems is thus exponential. Healthcare economics study is important to generate data as a basis for improving healthcare allocation, patient care and healthcare services, particularly in Asia where the healthcare system is relatively unprepared for such upcoming healthcare burden.

Asia-Pacific IBD Microbiota Consortium

The human intestinal microbiota is composed of complex community of commensal microorganisms. There is growing evidence that gut microbiota play an important role in pathogenesis of gastrointestinal disease and autoimmune disorder. Our IBD microbiota consortium aims to setup a biobank accompanied by a strong collaborative and scientific network in Asia-Pacific to investigate how microbiota influences diseases.

Study on Natural History

Data on the natural history of inflammatory bowel disease in population-based setting in Asia are scarce. It is not clear if IBD disease course differs between Asian and Western cohorts. We investigate disease outcome of IBD including but not limited to drug therapy, surgery, mortality, and cancer etc.

Genetics Study

Familial aggregation, twin studies, and recent genetic studies suggest that there is an important genetic component to IBD. In the West, genome wide association (GWA) studies have identified 163 loci associated with IBD. Many genes associated with CD include genes involved in bacterial handling, NOD 2, and the genes involved in autophagy ATG16L1 and IRGM. Only a few of these genes have been studied in Asian populations. Genetic studies in ethnically different populations may identify new causal variants in IBD, which are likely to lead to further insights into pathophysiology and potential treatments.


Contact Us
Contact Us

Principle Investigator
Prof Siew Ng, Prof Francis Chan, Prof Joseph Sung
email (Prof Siew Ng): siewchienng@cuhk.edu.hk

Study Coordinator
Miss Whitney Tang
email: whitneytang@cuhk.edu.hk

Institute of Digestive Disease, The Chinese University of Hong Kong
Room 94020, 7th Floor
Lui Che Woo Clinical Sciences Building,
Prince of Wales Hospital,
Shatin, N.T.,
HKSAR

Last Update: 11/9/2017
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