|We acknowledge the donation from Ferring Pharmaceuticals|
|Asia-Pacific Crohn's and Colitis Epidemiology Study|
|About Us||News and Updates||Current Studies||Contact Us||Investigators Login|
The Asia-Pacific Crohn's and Colitis Epidemiology Study is a collaboration project between 11 countries across Asia and Australia, focusing on research of Inflammatory Bowel Disease (IBD) in Asia-Pacific. In the past 2 decades, the incidence of IBD has been increasing in Asia. Yet, the reasons behind such changes remain largely unknown. They are unlikely to be merely increased awareness of the disease and differences in diagnostic practices, but most likely reflect real differences secondary to environmental factors, lifestyle and genetic susceptibility. We aim to fill the knowledge gap in our understanding of the epidemiology and natural history of IBD in Asia and hope to unravel factors responsible for the causation of IBD in Asia.
|News and Updates|
The Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies
Endoscopic and Histologic Mucosal Healing in Ulcerative Colitis in the First Year of Diagnosis: Results from a Population-Based Inception Cohort from Six Countries in Asia
Early Course of Inflammatory Bowel Disease in a Population-Based Inception Cohort Study From 8 Countries in Asia and Australia
Environmental Risk Factors in Inflammatory Bowel Disease: a Population-based
Case-control Study in Asia-Pacific
Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn's and Colitis Epidemiology Study
Temporal Trends of IBD in Asia-Pacific
IBD is increasing in Asia, however, the rate and frequency of increase is unknown. Temporal trends study will allow us to estimate the burden of IBD in the future. We plan to investigate disease incidence over the next 5 years.
IBD Healthcare Economics
IBD is a chronic diesase with a young age of onset. Its effects on health-care systems is thus exponential. Healthcare economics study is important to generate data as a basis for improving healthcare allocation, patient care and healthcare services, particularly in Asia where the healthcare system is relatively unprepared for such upcoming healthcare burden.
Asia-Pacific IBD Microbiota Consortium
The human intestinal microbiota is composed of complex community of commensal microorganisms. There is growing evidence that gut microbiota play an important role in pathogenesis of gastrointestinal disease and autoimmune disorder. Our IBD microbiota consortium aims to setup a biobank accompanied by a strong collaborative and scientific network in Asia-Pacific to investigate how microbiota influences diseases.
Study on Natural History
Data on the natural history of inflammatory bowel disease in population-based setting in Asia are scarce. It is not clear if IBD disease course differs between Asian and Western cohorts. We investigate disease outcome of IBD including but not limited to drug therapy, surgery, mortality, and cancer etc.
Familial aggregation, twin studies, and recent genetic studies suggest that there is an important genetic component to IBD. In the West, genome wide association (GWA) studies have identified 163 loci associated with IBD. Many genes associated with CD include genes involved in bacterial handling, NOD 2, and the genes involved in autophagy ATG16L1 and IRGM. Only a few of these genes have been studied in Asian populations. Genetic studies in ethnically different populations may identify new causal variants in IBD, which are likely to lead to further insights into pathophysiology and potential treatments.
Institute of Digestive Disease, The Chinese University of Hong Kong
Last Update: 11/9/2017
Copyright © 2017 The Chinese University of Hong Kong. All Rights Reserved.